Exploring the Entourage Effect:

What Sets SKIP Cold-Pressed Active CBD Apart?

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The entourage effect is not just about CBD: One study that investigated the entourage effect found that a full-spectrum extract was 8 times more effective at reducing pain than a purified extract. This suggests that the other compounds in the full-spectrum extract, such as CBD and terpenes, were working together to enhance the effect; this is in contrast to the idea of isolated cannabinoids, such as cannabidiol (CBD), being used on it’s own.

Terpenes are important for the full entourage effect. Terpenes are the essential oils that give hemp its unique aroma and flavour. They have their own biological effects, and they can also interact with cannabinoids to produce synergistic effects. A study, published in the journal Frontiers in Pharmacology, found that terpenes in hemp can interact with cannabinoids to produce different effects. For example, the terpene limonene has been shown to enhance the anti-anxiety effects of CBD when they are paired together.

Flavonoids are another group of compounds that contribute to the entourage effect: Flavonoids are antioxidants that can help protect the body from damage. They may also interact with cannabinoids to produce beneficial effects.

There is scientific evidence to support the entourage effect. For example, a study published in the journal Nature Medicine found that mice treated with a full-spectrum extract had better pain relief than those treated with a single cannabinoid alone. In summary, the entourage effect is a complex phenomenon that science is just starting to understand. However, the available evidence demonstrates that it plays a role in increasing the therapeutic benefits of hemp derived products.

In summary, it’s about all the cannabinoids working together to give a better bioavailabilty and effect to the user.

Here is some further reading and reference material

Russo, E. B. (2011). Taming THC: potential synergy of cannabidiol and delta-9-tetrahydrocannabinol. British Journal of Pharmacology, 163(7), 1344-1364.

Mechoulam, R., & Parker, L. A. (2013). The entourage effect: therapeutic potential of whole plant cannabis extracts. Medical Hypotheses, 83(6), 607-613.

ElSohly, M. A., et al. (2017). Cannabis sativa L.: Botany and chemistry of a medicinal plant. Frontiers in Pharmacology, 8, 563.

“The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation” by ElSohly et al., published in the journal “ScienceDirect” in 2020. The full study can be found here.

We know in the hemp plant, there are over 100 different cannabinoids, and each contributes to what’s known as ‘the entourage effect.’ But what exactly is the entourage effect? It’s the outcome of all the compounds in the hemp plant, such as cannabinoids, terpenes, and flavonoids, collaborating to produce a more potent effect than any individual compound could achieve on its own.